Structural and functional magnetic resonance imaging in isolated REM sleep behavior disorder: A systematic review of studies using neuroimaging software

Isolated rapid eye movement sleep behavior disorder (iRBD) is a harbinger for developing clinical synucleinopathies. Magnetic resonance imaging (MRI) has been suggested as tool understanding the brain bases of iRBD and its evolution. This review systematically analyzed original full text articles on structural functional MRI in patients with video-polysomnography-confirmed according to systematic procedures by Reviews Meta-analyses (PRISMA). The literature search was conducted via PubMed database related from 2000 2020. Investigations date have diverse terms methodology, but most agree that changes deep gray matter nuclei, cortical atrophy, disrupted connectivity within basal ganglia, cortico-striatal cortico-cortical networks. Furthermore, there evidence detects associated motor non-motor symptoms iRBD. current highlights need larger multicenter longitudinal studies, using complex approaches based data-driven unsupervised machine learning will help identify patterns degeneration. In turn, this may even allow prediction subsequent phenoconversion clinically defined